2034581-68-3
2034581-68-3
Chemical Structure
Glue02
- CAS No.: 2034581-68-3
- Formula:C15H15N7OS
- Molecular Weight:341.39
InChIKey: ZVSBPSJFPGTGBC-UHFFFAOYSA-N
SMILES: CC1=CN=C(NC(C2CN(C3=NC=NC(N4C=CC=N4)=C3)C2)=O)S1
Biological Activity: Glue02 is a CCNK molecular glue degrader with a DC50 < 0.1 μM. Glue02 binds to the kinase domain of CDK12, promotes the formation of a ternary complex between CDK12 and the DDB1-CUL4-RBX1 E3 ubiquitin ligase complex, converts CDK12 into a substrate-specific receptor, and induces polyubiquitination and proteasomal degradation of CCNK. Glue02 inhibits cancer cell proliferation. Glue02 can be used in cancer-related research[1].
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Glue02 | Glue02 is a CCNK molecular glue degrader with a DC50 < 0.1 μM. Glue02 binds to the kinase domain of CDK12, promotes the formation of a ternary complex between CDK12 and the DDB1-CUL4-RBX1 E3 ubiquitin ligase complex, converts CDK12 into a substrate-specific receptor, and induces polyubiquitination and proteasomal degradation of CCNK. Glue02 inhibits cancer cell proliferation. Glue02 can be used in cancer-related research. | |||||||||||||||||||||
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