2035480-78-3
Chemical Structure
DfTat
- CAS No.: 2035480-78-3
- Formula:C178H292N74O34S2
- Molecular Weight:4076.83
IUPAC Name: (1R,2R)-2-(pyridin-2-yldisulfanyl)cyclohexan-1-ol
SMILES: O=C([C@@H](N)CSSC[C@H](N)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)CCCNC(N)=N)=O)CCCCNC(C1=CC(C([O-])=O)=C(C=C1)C2=C3C=CC(N(C)C)=CC3=[O+]C4=C2C=CC(N(C)C)=C4)=O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)CCCNC(N)=N)=O)CCCCNC(C5=CC(C([O-])=O)=C(C=C5)C6=C7C=CC(N(C)C)=CC7=[O+]C8=C6C=CC(N(C)C)=C8)=O
Biological Activity: DfTat is a disulfide-linked dimeric cell-penetrating peptide derived from HIV-TAT, and can be used as a delivery enhancer. DfTat is composed of natural amino acids and is rapidly degraded intracellularly. DfTat is taken up via macropinocytosis, accumulates in late endosomes, binds to late endosomal BMP lipids, and co-delivers cell-impermeable drugs into the cytosol of live cells via endocytosis after co-incubation. DfTat can be used in research related to cytosolic drug delivery[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DfTat | 95.86% | DfTat is a disulfide-linked dimeric cell-penetrating peptide derived from HIV-TAT, and can be used as a delivery enhancer. DfTat is composed of natural amino acids and is rapidly degraded intracellularly. DfTat is taken up via macropinocytosis, accumulates in late endosomes, binds to late endosomal BMP lipids, and co-delivers cell-impermeable drugs into the cytosol of live cells via endocytosis after co-incubation. DfTat can be used in research related to cytosolic drug delivery. | ||||||||||||||||||||
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References
- [1]. Erazo-Oliveras A, et al. Protein delivery into live cells by incubation with an endosomolytic agent. Nature methods. 2014 Aug;11(8):861-7.
- [2]. Erazo-Oliveras A, et al. The Late Endosome and Its Lipid BMP Act as Gateways for Efficient Cytosolic Access of the Delivery Agent dfTAT and Its Macromolecular Cargos. Cell chemical biology. 2016 May 19;23(5):598-607.
- [3]. Allen JK, et al. In vivo peptide-based delivery of a gene-modifying enzyme into cells of the central nervous system. Science Advances. 2022 Sep 28;8(39):eabo2954.
- [4]. Tietz O, et al. Tricyclic cell-penetrating peptides for efficient delivery of functional antibodies into cancer cells. Nature chemistry. 2022 Mar;14(3):284-293.
- [5]. Reeman J, et al. Strength in numbers: cell penetrating peptide clusters to build next-generation therapeutics. Trends in Chemistry. 2024 Nov 1;6(11):669-83.
