2035814-50-5
Chemical Structure
JNJ-61432059
- CAS No.: 2035814-50-5
- Formula:C25H22FN5O2
- Molecular Weight:443.47
IUPAC Name: 5-(2-(4-fluorophenyl)-7-(4-hydroxypiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl)indolin-2-one
InChIKey: UWIJVELUZWBFEU-UHFFFAOYSA-N
SMILES: OC1CCN(C2=NC=CC3=C(C4=CC=C(NC(C5)=O)C5=C4)C(C6=CC=C(F)C=C6)=NN32)CC1
Biological Activity: JNJ-61432059 is a blood-brain barrier-permeable, orally active TARP γ-8-associated AMPAR modulator with anticonvulsant activity. JNJ-61432059 negatively regulates GluA1 and positively modulates GluA2-containing AMPARs. JNJ-61432059 exerts potent protective effects in rodent epilepsy models. JNJ-61432059 is applicable for epilepsy-related research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
JNJ-61432059 | 99.18% | JNJ-61432059 is a blood-brain barrier-permeable, orally active TARP γ-8-associated AMPAR modulator with anticonvulsant activity. JNJ-61432059 negatively regulates GluA1 and positively modulates GluA2-containing AMPARs. JNJ-61432059 exerts potent protective effects in rodent epilepsy models. JNJ-61432059 is applicable for epilepsy-related research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
JNJ-61432059 (Standard) | ≥98% | JNJ-61432059 (Standard) is the analytical standard of JNJ-61432059 (HY-111751). This product is intended for research and analytical applications. JNJ-61432059 is a blood-brain barrier-permeable, orally active TARP γ-8-associated AMPAR modulator with anticonvulsant activity. JNJ-61432059 negatively regulates GluA1 and positively modulates GluA2-containing AMPARs. JNJ-61432059 exerts potent protective effects in rodent epilepsy models without impairing motor function. JNJ-61432059 is applicable for epilepsy-related research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Savall BM, et al. Discovery of Imidazo[1,2-a]pyrazines and Pyrazolo[1,5-c]pyrimidines as TARP γ-8 Selective AMPAR Negative Modulators. ACS Med Chem Lett. 2018;10(3):267-272. Published 2018 Dec 26. [Content Brief]
- [2]. Zhang D, et al. Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics. Nat Commun. 2023;14(1):1659. Published 2023 Mar 25. [Content Brief]
