2036082-79-6
2036082-79-6
Chemical Structure
JNJ-56022486
- CAS No.: 2036082-79-6
- Formula:C15H10ClN3O
- Molecular Weight:283.71
IUPAC Name: 2-(3-chloro-2-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)phenyl)acetonitrile
InChIKey: WJCNWFPRVRWFCU-UHFFFAOYSA-N
SMILES: N#CCC1=CC=CC(Cl)=C1C2=CC=C(N3)C(NC3=O)=C2
Biological Activity: JNJ-56022486 is an orally active and potent negative AMPA receptor modulator (Ki=19 nM) selective for?TARP-γ8. JNJ-56022486 is also a TARP-γ8 receptor antagonist, with blood?brain?barrier (BBB) permeability. JNJ-56022486 can be used for research of Epilepsy[1][2].
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JNJ-56022486 | JNJ-56022486 is an orally active and potent negative AMPA receptor modulator (Ki=19 nM) selective for?TARP-γ8. JNJ-56022486 is also a TARP-γ8 receptor antagonist, with blood?brain?barrier (BBB) permeability. JNJ-56022486 can be used for research of Epilepsy. | |||||||||||||||||||||
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References
- [1]. Maher MP, et al. Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8. J Pharmacol Exp Ther. 2016 May;357(2):394-414. [Content Brief]
- [2]. Rosenbaum MI, et al. Targeting receptor complexes: a new dimension in drug discovery. Nat Rev Drug Discov. 2020 Dec;19(12):884-901. [Content Brief]
