2041072-41-5
2041072-41-5
Chemical Structure
ICCB280
- CAS No.: 2041072-41-5
- Formula:C23H18N2O4
- Molecular Weight:386.40
IUPAC Name: (E)-2-(3,4-dihydroxystyryl)-3-(2-methoxyphenyl)quinazolin-4(3H)-one
InChIKey: OTKDKQJFWIGZLU-ACCUITESSA-N
SMILES: O=C1N(C2=CC=CC=C2OC)C(/C=C/C3=CC=C(O)C(O)=C3)=NC4=C1C=CC=C4
Biological Activity: ICCB280 is a potent inducer of C/EBPα. ICCB280 exhibits anti-leukemic properties including terminal differentiation, proliferation arrest, and apoptosis through activation of C/EBPα and affecting its downstream targets (such as C/EBPε, G-CSFR and c-Myc)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ICCB280 | 98.14% | ICCB280 is a potent inducer of C/EBPα. ICCB280 exhibits anti-leukemic properties including terminal differentiation, proliferation arrest, and apoptosis through activation of C/EBPα and affecting its downstream targets (such as C/EBPε, G-CSFR and c-Myc). | ||||||||||||||||||||
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References
- [1]. Radomska HS, et, al. A Cell-Based High-Throughput Screening for Inducers of Myeloid Differentiation. J Biomol Screen. 2015 Oct;20(9):1150-9. [Content Brief]
- [2]. Sridhar R, et, al. Styryl Quinazolinones as Potential Inducers of Myeloid Differentiation via Upregulation of C/EBPα. Molecules. 2018 Aug 3;23(8):1938. [Content Brief]
