2042178-19-6
![[Nle20] H4 peptide (16−23) Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-p10570.gif "[Nle20] H4 peptide (16−23) Chemical Structure")
2042178-19-6
Chemical Structure
[Nle20] H4 peptide (16−23)
- CAS No.: 2042178-19-6
- Formula:C47H88N20O9
- Molecular Weight:1077.33
InChIKey: YTKGFQLYAICTMK-VTGDPKQBSA-N
SMILES: O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCC)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N
Biological Activity: [Nle20] H4 peptide (16−23) is a peptide with strong inhibitory activity against histone methyltransferase SETD8 (Kd=0.14 μM), which inhibits SETD8's methylation of histone H4 by competing with SETD8's substrate binding site. [Nle20] H4 peptide (16−23) can be used as a lead compound for anticancer therapy[1].
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[Nle20] H4 peptide (16−23) | [Nle20] H4 peptide (16−23) is a peptide with strong inhibitory activity against histone methyltransferase SETD8 (Kd=0.14 μM), which inhibits SETD8's methylation of histone H4 by competing with SETD8's substrate binding site. [Nle20] H4 peptide (16−23) can be used as a lead compound for anticancer therapy. | |||||||||||||||||||||
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