204274-74-8
Chemical Structure
RS 45041-190 hydrochloride
- CAS No.: 204274-74-8
- Formula:C11H13Cl2N3
- Molecular Weight:258.15
IUPAC Name: (1S,3R,4S,5R)-1,4-bis(((E)-3-(3,4-dihydroxyphenyl)acryloyl)oxy)-3,5-dihydroxycyclohexanecarboxylic acid
InChIKey: WRYJNVYEPVATQV-UHFFFAOYSA-N
SMILES: ClC1=CC=CC2=C1CN(C3=NCCN3)C2.Cl
Biological Activity: RS 45041-190 hydrochloride is a high-affinity ligand for I2 imidazoline receptors, with the pKis of 8.66, 9.37, 9.32, and 8.85 in rat, rabbit, dog and baboon kidney, respectively. RS 45041-190 hydrochloride shows moderate potency for the inhibition of monoamine oxidase A in vitro (pIC50= 6.12), but had much lower potency for monoamine oxidase B (pIC50 = 4.47)[1].
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RS 45041-190 hydrochloride | RS 45041-190 hydrochloride is a high-affinity ligand for I2 imidazoline receptors, with the pKis of 8.66, 9.37, 9.32, and 8.85 in rat, rabbit, dog and baboon kidney, respectively. RS 45041-190 hydrochloride shows moderate potency for the inhibition of monoamine oxidase A in vitro (pIC50= 6.12), but had much lower potency for monoamine oxidase B (pIC50 = 4.47). | |||||||||||||||||||||
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