2044-85-1
2044-85-1
Chemical Structure
2′,7′-Dichlorofluorescein diacetate
Synonym(s): DCFH2-DA
- CAS No.: 2044-85-1
- Formula:C24H14Cl2O7
- Molecular Weight:485.27
IUPAC Name: 2',7'-dichloro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl diacetate
InChIKey: VQVUBYASAICPFU-UHFFFAOYSA-N
SMILES: O=C1OC2(C3=C(OC4=C2C=C(Cl)C(OC(C)=O)=C4)C=C(OC(C)=O)C(Cl)=C3)C5=C1C=CC=C5
Biological Activity: 2′,7′-Dichlorofluorescein diacetate (DCFH2-DA) is a cell-permeable fluorescent probe. 2′,7′-Dichlorofluorescein diacetate can be used to detect the generation of reactive oxygen intermediates and for assessing the overall oxidative stress in toxicological phenomenon[1][2].
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2′,7′-Dichlorofluorescein diacetate | 99.16% | 2′,7′-Dichlorofluorescein diacetate (DCFH2-DA) is a cell-permeable fluorescent probe. 2′,7′-Dichlorofluorescein diacetate can be used to detect the generation of reactive oxygen intermediates and for assessing the overall oxidative stress in toxicological phenomenon. | ||||||||||||||||||||
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2′,7′-Dichlorofluorescein diacetate (solution) | 2′,7′-Dichlorofluorescein diacetate (DCFH2-DA) (solution) is a cell-permeable fluorescent probe. 2′,7′-Dichlorofluorescein diacetate can be used to detect the generation of reactive oxygen intermediates and for assessing the overall oxidative stress in toxicological phenomenon. Solvent and concentration: DMSO: 10 mM The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base. |
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References
- [1]. Afri M, et al. Active oxygen chemistry within the liposomal bilayer. Part IV: Locating 2',7'-dichlorofluorescein (DCF), 2',7'-dichlorodihydrofluorescein (DCFH) and 2',7'-dichlorodihydrofluorescein diacetate (DCFH-DA) in the lipid bilayer. Chem Phys Lipids. 2004 Aug;131(1):123-33. [Content Brief]
- [2]. Loetchutinat C, et al. Spectrofluorometric determination of intracellular levels of reactive oxygen species in drug-sensitive and drug-resistant cancer cells using the 2′, 7′-dichlorofluorescein diacetate assay[J]. Radiation Physics and Chemistry, 2005, 72(2-3): 323-331.
