205432-12-8
205432-12-8
Chemical Structure
JS-K
- CAS No.: 205432-12-8
- Formula:C13H16N6O8
- Molecular Weight:384.30
IUPAC Name: (Z)-2-(2,4-dinitrophenoxy)-1-(4-(ethoxycarbonyl)piperazin-1-yl)diazene 1-oxide
InChIKey: DNJRNBYZLPKSHV-RGEXLXHISA-N
SMILES: O=C(N1CCN(/[N+]([O-])=N/OC2=CC=C([N+]([O-])=O)C=C2[N+]([O-])=O)CC1)OCC
Biological Activity: JS-K is a NO donor that reacts with glutathione to generate NO at physiological pH. JS-K induces reactive oxygen species (ROS) to mediate apoptosis. JS-K induces autophagy. JS-K inhibits invasion. JS-K has a broad spectrum anti-proliferative activity in cancer cells. JS-K reduces tumor volume and causes necrosis of implanted tumors in mice[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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JS-K | 99.59% | JS-K is a NO donor that reacts with glutathione to generate NO at physiological pH. JS-K induces reactive oxygen species (ROS) to mediate apoptosis. JS-K induces autophagy. JS-K inhibits invasion. JS-K has a broad spectrum anti-proliferative activity in cancer cells. JS-K reduces tumor volume and causes necrosis of implanted tumors in mice. | ||||||||||||||||||||
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DPP-IV-IN-2 | 99.35% | DPP-IV-IN-2 is an inhibitor of both dipeptidyl peptidase IV (DPIV) and DP8/9 with IC50s of 0.1 and 0.95 μM, respectively. | ||||||||||||||||||||
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N-(2,4-Dinitrophenyl)glycine | 99.54% | N-(2,4-Dinitrophenyl)glycine is a Glycine (HY-Y0966) derivative. | ||||||||||||||||||||
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WWL229 | 99.49% | WWL229 is a selective inhibitor of carboxylesterase 3 (CES3) with an IC50 1.94 μM. WWL229 attenuates LPS (HY-D1056)-induced pro-inflammatory cytokine mRNA levels, inhibits lipolysis and adipose thermogenesis, impairs mitochondrial function, and promotes lipid storage. WWL229 can be used for the research of obesity, insulin resistance, type 2 diabetes, and lung inflammation. | ||||||||||||||||||||
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DNP-NH-PEG2-C2-acid | DNP-NH-PEG2-C2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. | |||||||||||||||||||||
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WWL154 | 98.96% | WWL154, an analog of JZL184 that maintains the SH-reactive p-nitrophenyl carbamate group, is a FAAH-4 inhibitor. | ||||||||||||||||||||
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Bcl-2-IN-10 | Bcl-2-IN-10 is an active Bcl-2 inhibitor that can release up to four nitric oxide (NO) molecules. Bcl-2-IN-10 has cytotoxic activities against cancer cells, such as human leukemia, breast cancer and lung cancer. Bcl-2-IN-10 induces cell apopotosis and arrest cell cycle of G2/M phase, and can be used in cancer-related research. | |||||||||||||||||||||
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AA38-3 | 99.95% | AA38-3 is a serine hydrolase (SH) inhibitor. AA38-3 can inhibit three SHs, ABHD6, ABHD11, and FAAH. | ||||||||||||||||||||
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NO donor-1 | NO donor-1 is a diol diazeniumdiolate-based Nitric oxide donor. | |||||||||||||||||||||
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Palbociclib impurity 20 | 99.91% | Palbociclib impurity 20 is an impurity of Palbociclib (HY-50767). | ||||||||||||||||||||
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Trimetazidine impurity 7 | Trimetazidine impurity 7 is an impurity of Trimetazidine. | |||||||||||||||||||||
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References
- [1]. Shami PJ, et al. JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity. Mol Cancer Ther. 2003 Apr;2(4):409-17. [Content Brief]
- [2]. Liu B, et al. JS-K, a nitric oxide donor, induces autophagy as a complementary mechanism inhibiting ovarian cancer. BMC Cancer. 2019 Jul 1;19(1):645. [Content Brief]
