2055172-61-5
Chemical Structure
(S)-KT109
- CAS No.: 2055172-61-5
- Formula:C27H26N4O
- Molecular Weight:422.52
IUPAC Name: (S)-(4-([1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)(2-benzylpiperidin-1-yl)methanone
InChIKey: JKJMWHULJIOKPJ-VWLOTQADSA-N
SMILES: O=C(N1[C@@H](CCCC1)CC2=CC=CC=C2)N3N=NC(C4=CC=C(C=C4)C5=CC=CC=C5)=C3
Biological Activity: (S)-KT109 is an inhibitor of diacylglycerol lipase β (DAGLβ) with low inhibitory activity (IC50 = 39.81 nM). (S)-KT109 has relatively low inhibitory activity against DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol (IC50 = 794.3 nM). (S)-KT109 also has relatively low inhibitory activity against α/β-amidase domain-containing 6 (ABHD6) (IC50 = 630.9 nM)[1].
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(S)-KT109 | (S)-KT109 is an inhibitor of diacylglycerol lipase β (DAGLβ) with low inhibitory activity (IC50 = 39.81 nM). (S)-KT109 has relatively low inhibitory activity against DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol (IC50 = 794.3 nM). (S)-KT109 also has relatively low inhibitory activity against α/β-amidase domain-containing 6 (ABHD6) (IC50 = 630.9 nM). | |||||||||||||||||||||
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