2055362-72-4
2055362-72-4
Chemical Structure
(Z)-Leukadherin-1
Synonym(s): ADH-503 free base
- CAS No.: 2055362-72-4
- Formula:C22H15NO4S2
- Molecular Weight:421.49
IUPAC Name: (Z)-4-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid
InChIKey: AEZGRQSLKVNPCI-UNOMPAQXSA-N
SMILES: O=C(O)C1=CC=C(C2=CC=C(/C=C(SC(N3CC4=CC=CC=C4)=S)/C3=O)O2)C=C1.[(Z)]
Biological Activity: (Z)-Leukadherin-1 (ADH-503 free base) is an orally active and allosteric CD11b agonist. (Z)-Leukadherin-1 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses[1].
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(Z)-Leukadherin-1 | (Z)-Leukadherin-1 (ADH-503 free base) is an orally active and allosteric CD11b agonist. (Z)-Leukadherin-1 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses. | |||||||||||||||||||||
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