2056097-81-3
2056097-81-3
Chemical Structure
Momelotinib-d4 dihydrochloride hydrate
Synonym(s): CYT387-d4 hydrochloride hydrate
- CAS No.: 2056097-81-3
- Formula:C23H22D4Cl2N6O3
- Molecular Weight:509.42
SMILES: N#CCNC(C(C=C1)=CC=C1C2=NC(NC3=CC=C(N4C([2H])([2H])COCC4([2H])[2H])C=C3)=NC=C2)=O.Cl.O.Cl
Biological Activity: Momelotinib-d4 (CYT387-d4) dihydrochloride hydrate is a deuterium labeled Momelotinib (HY-10961). Momelotinib (CYT387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50s of 11 nM and 18 nM,respectively. CYT387 shows much less activity against JAK3[1].
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Momelotinib-d4 dihydrochloride hydrate | Momelotinib-d4 (CYT387-d4) dihydrochloride hydrate is a deuterium labeled Momelotinib (HY-10961). Momelotinib (CYT387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50s of 11 nM and 18 nM,respectively. CYT387 shows much less activity against JAK3. | |||||||||||||||||||||
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