2059110-46-0
2059110-46-0
Chemical Structure
BiBET
- CAS No.: 2059110-46-0
- Formula:C26H30N10O3
- Molecular Weight:530.58
IUPAC Name: 3-methoxy-N-(2-(4-(1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)-N-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-amine
InChIKey: LQHDIGAYVSAVRJ-UHFFFAOYSA-N
SMILES: CN(CCOC1=CC=C(C2CCN(C3=NN4C(C=C3)=NN=C4OC)CC2)C=C1)C5=NN6C(C=C5)=NN=C6OC
Biological Activity: BiBET is a selective BRD4 inhibitor with a pKd of 11 for BRD4 (1,2). BiBET downregulates c-Myc. BiBET can be used in cancer research[1][2][3].
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BiBET | BiBET is a selective BRD4 inhibitor with a pKd of 11 for BRD4 (1,2). BiBET downregulates c-Myc. BiBET can be used in cancer research. | |||||||||||||||||||||
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References
- [1]. Waring MJ, et al. Potent and selective bivalent inhibitors of BET bromodomains. Nature chemical biology. 2016 Dec;12(12):1097-1104. [Content Brief]
- [2]. Guan X. Discovery of Fluorescence Polarization Probes and Inhibitors for Testis-Specific Bromodomain and Extra-Terminal (BRDT) Proteins[J]. 2020.
- [3]. Watts E. Design and Synthesis of Dual KinaseBromodomain Inh ibitors Targeting ALK and BRD4[J]. 2019.
