206055-69-8
206055-69-8
Chemical Structure
2'-O,4'-C-Methylenecytidine
Synonym(s): LNA-C(Bz)
- CAS No.: 206055-69-8
- Formula:C10H13N3O5
- Molecular Weight:255.23
IUPAC Name: 4-amino-1-((1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl)pyrimidin-2(1H)-one
InChIKey: FCMRQQIZHFHCNG-JIOCBJNQSA-N
SMILES: OC[C@]1(CO2)[C@@H](O)[C@@H]2[C@H](N3C=CC(N)=NC3=O)O1
Biological Activity: 2'-O,4'-C-Methylenecytidine (LNA-C(Bz)) is a bicyclic nucleoside analogue with fixed N-type conformation. 2'-O,4'-C-Methylenecytidine can be used to synthesize oligonucleotides. 2'-O,4'-C-Methylenecytidine forms duplexes with complementary DNA and RNA strands[1][2].
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2'-O,4'-C-Methylenecytidine | 98.59% | 2'-O,4'-C-Methylenecytidine (LNA-C(Bz)) is a bicyclic nucleoside analogue with fixed N-type conformation. 2'-O,4'-C-Methylenecytidine can be used to synthesize oligonucleotides. 2'-O,4'-C-Methylenecytidine forms duplexes with complementary DNA and RNA strands. | ||||||||||||||||||||
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References
- [1]. bicyclic nucleoside analogue, N-type conformation, synthesize oligonucleotides, duplexes
- [2]. Obika S, et, al. Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides. Tetrahedron Letters. 1998 Jul 23; 39(30):5401-04.
