2064269-82-3
2064269-82-3
Chemical Structure
Pruvonertinib
Synonym(s): YK-029A
- CAS No.: 2064269-82-3
- Formula:C27H32N8O2
- Molecular Weight:500.60
InChIKey: OEFWUILIMFIVSE-UHFFFAOYSA-N
SMILES: C=CC(NC1=CC(NC2=NC=CC(C3=CN=C4C(C)=CC=CN43)=N2)=C(OC)C=C1N(CCN(C)C)C)=O
Biological Activity: YK-029A is an orally active inhibitor of mutant EGFR，targeting to both the T790M mutations (EGFRT790M) and exon 20 insertion of EGFR (EGFRex20ins). YK-029A exhibits significant antitumor activity，and results tumor regression in EGFRex20ins-driven PDX models[1].
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Pruvonertinib | 99.50% | YK-029A is an orally active inhibitor of mutant EGFR，targeting to both the T790M mutations (EGFRT790M) and exon 20 insertion of EGFR (EGFRex20ins). YK-029A exhibits significant antitumor activity，and results tumor regression in EGFRex20ins-driven PDX models. | ||||||||||||||||||||
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