2065197-82-0
Chemical Structure
MMV1557817
- CAS No.: 2065197-82-0
- Formula:C20H21F3N2O3
- Molecular Weight:394.39
InChIKey: NRAVUPOEFDEIOQ-UHFFFAOYSA-N
SMILES: CC(C)(CC(NC(C1=CC=C(C=C1)C2=CC(F)=C(C(F)=C2)F)C(NO)=O)=O)C
Biological Activity: MMV1557817 is an orally active dual aminopeptidase (Aminopeptidase) inhibitor. MMV1557817 targets multiple parasite life cycle stages by inhibiting M1 alanyl aminopeptidase and M17 leucyl aminopeptidase involved in terminal Hemoglobin (HY-P2995) digestion (PfA-M1 Ki = 269 nM; PfA-M17 Ki = 101 nM), exhibits broad cross-species antiplasmodial activity, and clears P. berghei infection in a mouse model. MMV1557817 can be used for research on malaria[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MMV1557817 | 99.06% | MMV1557817 is an orally active dual aminopeptidase (Aminopeptidase) inhibitor. MMV1557817 targets multiple parasite life cycle stages by inhibiting M1 alanyl aminopeptidase and M17 leucyl aminopeptidase involved in terminal Hemoglobin (HY-P2995) digestion (PfA-M1 Ki = 269 nM; PfA-M17 Ki = 101 nM), exhibits broad cross-species antiplasmodial activity, and clears P. berghei infection in a mouse model. MMV1557817 can be used for research on malaria. | ||||||||||||||||||||
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References
- [1]. Okombo J, et al. Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages. PLoS pathogens. 2022 Oct;18(10):e1010926.
- [2]. Mansouri M, et al. Novel Scaffold Unlocks Potent Cross-Peptidase and Cross-Species Inhibitors as Promising Antimalarial Agents. Journal of medicinal chemistry. 2026 Jan 22;69(2):1358-1386. [Content Brief]
- [3]. Edgar RCS, et al. On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity. mBio. 2024 Jun 12;15(6):e0096624. [Content Brief]
- [4]. Lim SYM, et al. Aminopeptidase Inhibition in Drug-Resistant Plasmodium falciparum: Structural, Functional, and Pharmacological Rationale for Targeting PfA-M1 and PfA-M17. ChemMedChem. 2026 Jul 29;21(14):e70401.
- [5]. Ji Y, et al. Validation of solvent proteome profiling for antimalarial drug target deconvolution. International journal for parasitology. Drugs and drug resistance. 2025 Dec;29:100626.
