2069220-61-5
2069220-61-5
Chemical Structure
BLT2 antagonist-1
- CAS No.: 2069220-61-5
- Formula:C26H26FNO4
- Molecular Weight:435.49
InChIKey: NPBCXBMRRPORQY-UHFFFAOYSA-N
SMILES: O=C(CCCC)N(C1=CC=CC(F)=C1)CC2=CC=C(C3=CC=C(OCC(O)=O)C=C3)C=C2
Biological Activity: BLT2 antagonist-1 (compound 15b) is a selective BLT2 antagonist that inhibits the chemotaxis of CHO-BLT2 cells with an IC50 of 224 nM. BLT2 antagonist-1 does not inhibits the chemotaxis of CHO-BLT1 cells. BLT2 antagonist-1 also inhibits the binding of LTB4 and BLT2 with a Ki value of 132 nM. BLT2 antagonist-1 can be used for the research of the inflammatory airway diseases such as asthma and chronic obstructive pulmonary disease[1].
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BLT2 antagonist-1 | BLT2 antagonist-1 (compound 15b) is a selective BLT2 antagonist that inhibits the chemotaxis of CHO-BLT2 cells with an IC50 of 224 nM. BLT2 antagonist-1 does not inhibits the chemotaxis of CHO-BLT1 cells. BLT2 antagonist-1 also inhibits the binding of LTB4 and BLT2 with a Ki value of 132 nM. BLT2 antagonist-1 can be used for the research of the inflammatory airway diseases such as asthma and chronic obstructive pulmonary disease. | |||||||||||||||||||||
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