2070916-70-8
Chemical Structure
PPI-GIT1/β-Pix PPI-IN-1
- CAS No.: 2070916-70-8
- Formula:C23H21NO5
- Molecular Weight:391.42
IUPAC Name: ethyl (1S,2R,3R,4S,E)-6-(furan-3-ylmethylene)-1'-methyl-2',5-dioxospiro[bicyclo[2.2.1]heptane-2,3'-indoline]-3-carboxylate
InChIKey: RLZMEKDCXNWDNP-ORQQMLAUSA-N
SMILES: O=C([C@@H]1[C@@H](C(OCC)=O)[C@]2(C(N(C)C3=C2C=CC=C3)=O)[C@H]/4C1)C4=C\C5=COC=C5
Biological Activity: PPI-GIT1/β-Pix interaction-IN-1 is a potent and orally active GIT1/β-Pix protein-protein interaction (PPI) inhibitor with a KD value of 7.7 µM. PPI-GIT1/β-Pix interaction-IN-1 disrupts the GIT/PIX interaction can impact the activation of the downstream Rho GTPase Rac1 and Cdc42. PPI-GIT1/β-Pix interaction-IN-1 inhibits metastasis of gastric cancer[1].
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PPI-GIT1/β-Pix PPI-IN-1 | 99.01% | PPI-GIT1/β-Pix interaction-IN-1 is a potent and orally active GIT1/β-Pix protein-protein interaction (PPI) inhibitor with a KD value of 7.7 µM. PPI-GIT1/β-Pix interaction-IN-1 disrupts the GIT/PIX interaction can impact the activation of the downstream Rho GTPase Rac1 and Cdc42. PPI-GIT1/β-Pix interaction-IN-1 inhibits metastasis of gastric cancer. | ||||||||||||||||||||
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