207993-12-2
207993-12-2
Chemical Structure
Pumafentrine
- CAS No.: 207993-12-2
- Formula:C29H39N3O3
- Molecular Weight:477.64
IUPAC Name: 4-((4aS,10bR)-9-ethoxy-8-methoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin-6-yl)-N,N-diisopropylbenzamide
InChIKey: CVDXFPBVOIERBH-DQEYMECFSA-N
SMILES: COC1=C(OCC)C=C([C@@]2([H])[C@@](CCN(C2)C)([H])N=C3C4=CC=C(C=C4)C(N(C(C)C)C(C)C)=O)C3=C1
Biological Activity: Pumafentrine is an orally active, potent dual PDE3/PDE4 inhibitor. Pumafentrine dose-dependently ameliorates the clinical score and colonic TNFα production in murine Dextran sulphate sodium (DSS; HY-116282C)-induced colitis in a preventive setting[1].
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Pumafentrine | Pumafentrine is an orally active, potent dual PDE3/PDE4 inhibitor. Pumafentrine dose-dependently ameliorates the clinical score and colonic TNFα production in murine Dextran sulphate sodium (DSS; HY-116282C)-induced colitis in a preventive setting. | |||||||||||||||||||||
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