208106-41-6
Chemical Structure
Poly-L-γ-glutamic acid sodium
- CAS No.: 208106-41-6
- Formula:N/A
- Molecular Weight:750000 (minimum)
SMILES: [Poly-L-g-glutamic acid (sodium)]
Biological Activity: Poly-L-γ-glutamic acid sodium is a macromolecular polymer formed by the linkage of glutamic acid residues via peptide bonds between γ-amino and carboxyl groups. Poly-L-γ-glutamic acid sodium plays an important role as a carrier material in compound delivery systems. Poly-L-γ-glutamic acid sodium can deliver Paclitaxel (HY-B0015) to colon cancer cells, reduce cell viability and inhibit the growth of colon cancer spheroids. Poly-L-γ-glutamic acid sodium can be used as a carrier material and in studies related to colon cancer in mice[1][2].
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Poly-L-γ-glutamic acid sodium | Poly-L-γ-glutamic acid sodium is a macromolecular polymer formed by the linkage of glutamic acid residues via peptide bonds between γ-amino and carboxyl groups. Poly-L-γ-glutamic acid sodium plays an important role as a carrier material in compound delivery systems. Poly-L-γ-glutamic acid sodium can deliver Paclitaxel (HY-B0015) to colon cancer cells, reduce cell viability and inhibit the growth of colon cancer spheroids. Poly-L-γ-glutamic acid sodium can be used as a carrier material and in studies related to colon cancer in mice. | |||||||||||||||||||||
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References
- [1]. Riku Kawasaki, et al. Water solubilization of paclitaxel using polypeptides for cancer therapy. Mater. Adv., 2022, 3, 467-473
- [2]. Jaimes-Aguirre L, et al. Biodegradable poly(D,L-lactide-co-glycolide)/poly(L-γ-glutamic acid) nanoparticles conjugated to folic acid for targeted delivery of doxorubicin. Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:743-751. [Content Brief]
