208445-06-1
Chemical Structure
Rp-8-Br-cGMPS sodium
Synonym(s): Rp-8-bromo-Cyclic GMPS sodium
- CAS No.: 208445-06-1
- Formula:C10H10BrN5NaO6PS
- Molecular Weight:462.15
IUPAC Name: sodium (2R,4aR,6R,7R,7aS)-6-(2-amino-8-bromo-6-oxo-3,6-dihydro-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2-thiolate 2-oxide
InChIKey: CHTSSROWUAICIL-HUSULMCLSA-M
SMILES: O=C1C2=C(N([C@H]3[C@H](O)[C@H](O4)[C@@H](CO[P@]4(S[Na])=O)O3)C(Br)=N2)NC(N)=N1
Biological Activity: Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt is a potent Ca2+-ATPase activator. Rp-8-Br-cGMPS is also an agonist of the rod CNG channel and an inhibitor of PKG. Rp-8-Br-cGMPS sodium salt mediates cytosolic Ca2+ reduction by activating Ca2+-ATPase and subsequently removing Ca2+ from the cell[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Rp-8-Br-cGMPS sodium | 99.7% | Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt is a potent Ca2+-ATPase activator. Rp-8-Br-cGMPS is also an agonist of the rod CNG channel and an inhibitor of PKG. Rp-8-Br-cGMPS sodium salt mediates cytosolic Ca2+ reduction by activating Ca2+-ATPase and subsequently removing Ca2+ from the cell. | ||||||||||||||||||||
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References
- [1]. Rashatwar SS, et, al. Effects of 8-bromo-cGMP on Ca2+ levels in vascular smooth muscle cells: possible regulation of Ca2+-ATPase by cGMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1987 Aug;84(16):5685-9. [Content Brief]
- [2]. Barnstable CJ, et al. Modulation of synaptic function by cGMP and cGMP-gated cation channels. Neurochem Int. 2004 Nov;45(6):875-84. [Content Brief]
