2088132-99-2
2088132-99-2
Chemical Structure
EZH2-IN-4
- CAS No.: 2088132-99-2
- Formula:C29H41N3O3S
- Molecular Weight:511.72
IUPAC Name: 5-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-((R)-1-((1r,4R)-4-(3-methoxyazetidin-1-yl)cyclohexyl)ethyl)-3-methyl-5,6,7,8-tetrahydro-4H-thieno[3,2-c]azepin-4-one
InChIKey: AGTKUHSJKOLBGH-CEMLEFRQSA-N
SMILES: CC1=C([C@@H]([C@@]2([H])CC[C@@](N3CC(C3)OC)([H])CC2)C)SC(CCCN4CC5=C(C=C(NC5=O)C)C)=C1C4=O
Biological Activity: EZH2-IN-4 is an orally active, potent EZH2 inhibitor with IC50s of 0.923 nM and 2.65 nM against wild type (WT) 5-membered (5-mer) EZH2 and mutant 5-mer EZH2, respectively. EZH2-IN-4 has anti-cancer activity[1].
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EZH2-IN-4 | EZH2-IN-4 is an orally active, potent EZH2 inhibitor with IC50s of 0.923 nM and 2.65 nM against wild type (WT) 5-membered (5-mer) EZH2 and mutant 5-mer EZH2, respectively. EZH2-IN-4 has anti-cancer activity. | |||||||||||||||||||||
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