2088234-50-6
Chemical Structure
β2AR-IN-15
- CAS No.: 2088234-50-6
- Formula:C34H39BrN4O4
- Molecular Weight:647.60
IUPAC Name: 4-((2S)-3-(((S)-3-(3-bromophenyl)-1-(methylamino)-1-oxopropan-2-yl)amino)-2-(2-cyclohexyl-2-phenylacetamido)-3-oxopropyl)benzamide
InChIKey: MZHSBVCCCRUZKX-ZTURCVLQSA-N
SMILES: O=C(N)C1=CC=C(C[C@H](NC(C(C2CCCCC2)C3=CC=CC=C3)=O)C(N[C@@H](CC4=CC=CC(Br)=C4)C(NC)=O)=O)C=C1
Biological Activity: β2AR-IN-15 is a selective β2-adrenergic receptor (β2AR) antagonist with a Kd of 1.7 μM. β2AR-IN-15 binds to an intracellular β2AR region overlapping the G-protein binding site, enhancing orthosteric inverse agonist binding while negatively modulating binding of orthosteric agonists with EC50 values of 1.9 and 0.48 μM. β2AR-IN-15 shows inhibitory effect on cAMP production and β-arrestin recruitment to activated β2AR. β2AR-IN-15 can be used for the research of cardiovascular and pulmonary diseases[1].
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β2AR-IN-15 | 98.84% | β2AR-IN-15 is a selective β2-adrenergic receptor (β2AR) antagonist with a Kd of 1.7 μM. β2AR-IN-15 binds to an intracellular β2AR region overlapping the G-protein binding site, enhancing orthosteric inverse agonist binding while negatively modulating binding of orthosteric agonists with EC50 values of 1.9 and 0.48 μM. β2AR-IN-15 shows inhibitory effect on cAMP production and β-arrestin recruitment to activated β2AR. β2AR-IN-15 can be used for the research of cardiovascular and pulmonary diseases. | ||||||||||||||||||||
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