2088243-03-0
Chemical Structure
NS5A-IN-4
- CAS No.: 2088243-03-0
- Formula:C47H48N8O6
- Molecular Weight:820.93
IUPAC Name: methyl ((S)-1-((S)-2-(5-(6-((2-((S)-1-((R)-2-((methoxycarbonyl)amino)-2-phenylacetyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)buta-1,3-diyn-1-yl)-[1,1'-biphenyl]-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate
InChIKey: IQVKTVMOKCCANC-SXXQQZPASA-N
SMILES: COC(N[C@@H](C(C)C)C(N1[C@H](C2=NC=C(C3=CC(C4=CC=CC=C4)=C(C=C3)C#CC#CC5=CN=C([C@H]6N(CCC6)C([C@@H](C7=CC=CC=C7)NC(OC)=O)=O)N5)N2)CCC1)=O)=O
Biological Activity: NS5A-IN-4 (Compound 1.12) is an orally active pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with IC50 values of 1.2, 2296, 4.6, 362, 10.3 and 693 pM against gT1b, gT1a, gT2a, gT3a, gT4a and gT5a[1]. NS5A-IN-4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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NS5A-IN-4 | NS5A-IN-4 (Compound 1.12) is an orally active pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with IC50 values of 1.2, 2296, 4.6, 362, 10.3 and 693 pM against gT1b, gT1a, gT2a, gT3a, gT4a and gT5a. NS5A-IN-4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | |||||||||||||||||||||
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