2088415-78-3
Chemical Structure
TMPRSS6-IN-1
- CAS No.: 2088415-78-3
- Formula:C33H40N8O4S2
- Molecular Weight:676.85
IUPAC Name: (S)-N-((S)-1-(benzo[d]thiazol-2-yl)-5-guanidino-1-oxopentan-2-yl)-3-methyl-2-((S)-2-(3-phenylpropanamido)-3-(thiazol-4-yl)propanamido)butanamide
InChIKey: JFPVABWUQNRDDL-VBOOUTDYSA-N
SMILES: NC(NCCC[C@H](NC([C@@H](NC([C@@H](NC(CCC1=CC=CC=C1)=O)CC2=CSC=N2)=O)C(C)C)=O)C(C3=NC4=C(S3)C=CC=C4)=O)=N
Biological Activity: TMPRSS6-IN-1 (compound 8) is a potent inhibitor of TMPRSS6 (Matriptase-2), belonging to TTSPs (transmembrane serine protease). TMPRSS6, is a type II TTSP, the genetic reduction of which will improve symptoms of hemochromatosis and beta thalassemia in mice[1].
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TMPRSS6-IN-1 | TMPRSS6-IN-1 (compound 8) is a potent inhibitor of TMPRSS6 (Matriptase-2), belonging to TTSPs (transmembrane serine protease). TMPRSS6, is a type II TTSP, the genetic reduction of which will improve symptoms of hemochromatosis and beta thalassemia in mice. | |||||||||||||||||||||
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