2088505-67-1
Chemical Structure
Glycybridin C
- CAS No.: 2088505-67-1
- Formula:C25H30O5
- Molecular Weight:410.50
InChIKey: YEROQRRJBUNBOY-HSZRJFAPSA-N
SMILES: C/C(C)=C\CC(C=C1C[C@@H](O)C(C2=C(C(C/C=C(C)\C)=C(C=C2)O)O)=O)=C(C=C1)O
Biological Activity: Glycybridin C is a Protein tyrosine phosphatase 1B (PTP1B) inhibitor and pregnane X receptor (PXR) ligand. Glycybridin C inhibits insulin and leptin signaling pathway negative regulation, LPS (HY-D1056)-induced NF-κB transcriptional activity. Glycybridin C forms hydrophobic and π-π stacking interactions with Met243, Phe288, Tyr306, and His407 residues of PXR. Glycybridin C can be used for the research of hepatocellular carcinoma, colorectal adenocarcinoma, breast carcinoma[1][2].
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Glycybridin C | Glycybridin C is a Protein tyrosine phosphatase 1B (PTP1B) inhibitor and pregnane X receptor (PXR) ligand. Glycybridin C inhibits insulin and leptin signaling pathway negative regulation, LPS (HY-D1056)-induced NF-κB transcriptional activity. Glycybridin C forms hydrophobic and π-π stacking interactions with Met243, Phe288, Tyr306, and His407 residues of PXR. Glycybridin C can be used for the research of hepatocellular carcinoma, colorectal adenocarcinoma, breast carcinoma. | |||||||||||||||||||||
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References
- [1]. Li K, et al. Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra. J Nat Prod. 2017 Feb 24;80(2):334-346. [Content Brief]
- [2]. Alhusban M, et al. Computational Tools to Expedite the Identification of Potential PXR Modulators in Complex Natural Product Mixtures: A Case Study with Five Closely Related Licorice Species. ACS Omega. 2022;7(30):26824-26843. Published 2022 Jul 21. [Content Brief]
