2089590-80-5
Chemical Structure
MZH29
- CAS No.: 2089590-80-5
- Formula:C31H33FN4O5
- Molecular Weight:560.62
IUPAC Name: 1-(3-fluoro-4-((6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yl)oxy)phenyl)-3-(m-tolyl)urea
InChIKey: YCKUFUAEVQPEBU-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(C)=C1)NC2=CC=C(OC3=CC=NC4=CC(OCCCN5CCOCC5)=C(OC)C=C34)C(F)=C2
Biological Activity: MZH29 is a potent and orally active FLT3 inhibitor. MZH29 shows inhibitory effects on wild-type and mutant FLT3, including the FLT3-ITD, FLT3-D835H/Y/V and FLT3-K663Q mutants. MZH29 retains its potent inhibitory effect against the FLT3-ITD/F691L mutation, a drug resistance mutation against the well-known FLT3 inhibitor, AC220 (HY-13001). MZH29 can be used for the research of cancer, such as acute myeloid leukemia (AML)[1].
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MZH29 | MZH29 is a potent and orally active FLT3 inhibitor. MZH29 shows inhibitory effects on wild-type and mutant FLT3, including the FLT3-ITD, FLT3-D835H/Y/V and FLT3-K663Q mutants. MZH29 retains its potent inhibitory effect against the FLT3-ITD/F691L mutation, a drug resistance mutation against the well-known FLT3 inhibitor, AC220 (HY-13001). MZH29 can be used for the research of cancer, such as acute myeloid leukemia (AML). | |||||||||||||||||||||
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