209323-98-8
209323-98-8
Chemical Structure
Cys-Penetratin
- CAS No.: 209323-98-8
- Formula:C107H173N35O21S2
- Molecular Weight:2349.87
IUPAC Name: L-alanyl-L-prolyl-L-tryptophyl-L-histidyl-L-leucyl-L-seryl-L-seryl-L-glutaminyl-L-tyrosyl-L-seryl-L-arginyl-L-threonine
SMILES: NCCCC[C@@H](C(O)=O)NC([C@H](CCCCN)NC([C@H](CC1=CNC2=CC=CC=C12)NC([C@H](CCCCN)NC([C@H](CCSC)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(N)=O)NC([C@H](CCC(N)=O)NC([C@H](CC3=CC=CC=C3)NC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@H](CCCCN)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(N)=O)NC([C@@H](NC([C@@H](N)CS)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: Cys-Penetratin is a cysteine-containing cell-penetrating peptide with sequence CRQIKIWFQNRRMKWKK. Cys-Penetratin can Cys-Penetratin can be used for the research for the research of drug delivery[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cys-Penetratin | 96.37% | Cys-Penetratin is a cysteine-containing cell-penetrating peptide with sequence CRQIKIWFQNRRMKWKK. Cys-Penetratin can Cys-Penetratin can be used for the research for the research of drug delivery. | ||||||||||||||||||||
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Antennapedia Peptide | 98.35% | Antennapedia Peptide (Penetratin peptide) is a 16 amino acid peptide, originally derived from the 60 amino acid long homeodomain of the Drosophila transcription factor Antennapedia and is a member of the family of cell-penetrating peptides. | ||||||||||||||||||||
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Penetratin-Cys | Penetratin-Cys is a cell-penetrating peptide derived from Antennapedia Peptide (HY-P0307) via C-terminal cysteine modification. Penetratin-Cys acts as a cytotoxin and reduces the viability of differentiated neuronal cells. Penetratin-Cys localizes to the perinuclear region and binds to the Golgi apparatus. Penetratin-Cys can be used in research related to neurological disorders. | |||||||||||||||||||||
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PTD | PTD (Antennapedia leader peptide) is a negative control of TRAF6 inhibitor peptide DRQIKIWFQNRRMKWKK-RKIPTEDEY. | |||||||||||||||||||||
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Proadrenomedullin (1-20), human | 99.53% | Proadrenomedullin (1-20), human is a potent hypotensive and catecholamine release–inhibitory peptide released from chromaffin cells. Proadrenomedullin (1-20) inhibits catecholamine secretion in PC12 pheochromocytoma cells (IC50 ≈ 350 nM) by suppressing Na+/Ca2+ influx and blocking desensitization. Proadrenomedullin (1-20), human specifically acts on nicotinic cholinergic receptors in a non competitive manner. Proadrenomedullin (1-20), human can be used for research on conditions such as hypertension. | ||||||||||||||||||||
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Penetratin | 99.98% | Penetratin is a cell-penetrating peptides derived from a nonviral protein. Penetratin can powerfully enhance drug absorption. Penetratin can be used for drug delivery research in the treatment of various diseases. | ||||||||||||||||||||
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Antennapedia Leader Peptide (CT) | Antennapedia Leader Peptide (CT) is a cell penetrating peptide that can be used for drug delivery. | |||||||||||||||||||||
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Antennapedia Peptide, amide | Antennapedia Peptide, amide is a C-terminal amide cell-penetrating peptide. | |||||||||||||||||||||
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Plsl | Plsl is a cell-penetrating peptide (CPP), with sequence of RVIRVWFQNKRCKDKK. Plsl, belongs to Penetralia family, and origins from Igl-1 homeodomain. | |||||||||||||||||||||
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Penetratin-Arg | 98.17% | Penetratin-Arg is an antimicrobial and is used for drug delivery vehicle. | ||||||||||||||||||||
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Proadrenomedullin (N-20) (bovine, porcine) | Proadrenomedullin (N-20) (ProADM N20) (bovine, porcine) is a potent and noncompetitive hypotensive and catecholamine release-inhibitory peptide released from chromaffin cells. Proadrenomedullin (N-20) (bovine, porcine) inhibits catecholamine secretion with an IC50 of 350 nM in PC12 pheochromocytoma cells. Proadrenomedullin (N-20) (bovine, porcine) also blocks (EC50≈270 nM) nicotinic cholinergic agonist desensitization of catecholamine release, as well as desensitization of nicotinic signal transduction (22Na+ uptake). | |||||||||||||||||||||
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References
- [1]. Keum T, et al. Examination of Effective Buccal Absorption of Salmon Calcitonin Using Cell-Penetrating Peptide-Conjugated Liposomal Drug Delivery System. Int J Nanomedicine. 2022;17:697-710. Published 2022 Feb 15. [Content Brief]
- [2]. Sadowsky JD, et al. Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein- and Peptide-Payload Conjugates: Application to THIOMAB Antibody-Drug Conjugates. Bioconjug Chem. 2017;28(8):2086-2098. [Content Brief]
