2097104-58-8
2097104-58-8
Chemical Structure
Spesolimab (WT IgG1)
Synonym(s): BI 655130 (WT IgG1)
- CAS No.: 2097104-58-8
- Formula:N/A
- Molecular Weight:(145.5 kDa)
SMILES: [Spesolimab (WT IgG1)]
Biological Activity: Spesolimab (BI 655130) (WT IgG1) is a mouse-derived humanized IgG1k antibody against IL-36R. Spesolimab (WT IgG1) retains the native wild-type Fc. Spesolimab (WT IgG1) is associated with a reduction in biomarkers associated with the innate, Th1/Th17 and neutrophil pathways. Spesolimab (WT IgG1) is being investigated in palmoplantar pustulosis (PPP)[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Spesolimab (WT IgG1) | 99.10% | Spesolimab (BI 655130) (WT IgG1) is a mouse-derived humanized IgG1k antibody against IL-36R. Spesolimab (WT IgG1) retains the native wild-type Fc. Spesolimab (WT IgG1) is associated with a reduction in biomarkers associated with the innate, Th1/Th17 and neutrophil pathways. Spesolimab (WT IgG1) is being investigated in palmoplantar pustulosis (PPP). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Mrowietz U, et al. Spesolimab, an Anti-Interleukin-36 Receptor Antibody, in Patients with Palmoplantar Pustulosis: Results of a Phase IIa, Multicenter, Double-Blind, Randomized, Placebo-Controlled Pilot Study. Dermatol Ther (Heidelb). 2021 Apr;11(2):571-585. [Content Brief]
- [2]. Geller S, et al. CCR4 expression in CD8+ cutaneous T-cell lymphomas and lymphoproliferative disorders and its implications for diagnosis and treatment[C]//Journal of Investigative Dermatology. STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA: ELSEVIER SCIENCE INC, 2019, 139(9): B25-B25.
- [3]. Jennifer Ahlberg, et al. Retrospective analysis of model-based predictivity of human pharmacokinetics for anti-IL-36R monoclonal antibody MAB92 using a rat anti-mouse IL-36R monoclonal antibody and RNA expression data (FANTOM5). MAbs. 2019 Jul;11(5):956-964. [Content Brief]
- [4]. Rajkumar Ganesan, et al. Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies.MAbs. 2017 Oct;9(7):1143-1154. [Content Brief]
