2097497-16-8
Chemical Structure
Anticancer agent 109
- CAS No.: 2097497-16-8
- Formula:C19H15N3O2
- Molecular Weight:317.34
IUPAC Name: (Z)-5-hydroxy-4,6-dimethyl-3-(quinolin-2-ylmethylene)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one
InChIKey: CSKXBCHNPARCGH-ZROIWOOFSA-N
SMILES: O=C(/C(C1=C2C)=C\C3=NC4=C(C=CC=C4)C=C3)NC1=NC(C)=C2O
Biological Activity: Anticancer agent 109 (compound 6-15) is an inhibitor of the Gas6-Axl axis with anti-cancer activity. Anticancer agent 109 inhibits the expression of Gas6 and Axl, and the expression p-PI3K and p-AKT in cancer cells, leads to G1 phase arrest and promotes cancer cells apoptosis, and inhibits tumor growth significantly in nude mouse tumor bearing models[1].
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Anticancer agent 109 | Anticancer agent 109 (compound 6-15) is an inhibitor of the Gas6-Axl axis with anti-cancer activity. Anticancer agent 109 inhibits the expression of Gas6 and Axl, and the expression p-PI3K and p-AKT in cancer cells, leads to G1 phase arrest and promotes cancer cells apoptosis, and inhibits tumor growth significantly in nude mouse tumor bearing models. | |||||||||||||||||||||
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