2097535-26-5
Chemical Structure
AcdK
- CAS No.: 2097535-26-5
- Formula:C14H17N5O4
- Molecular Weight:319.32
InChIKey: PZTYUDVWRLLLOP-NKWNXKNASA-N
SMILES: OC([C@@H](N)CC/C=C/NC(OCC1=CC=C(C=C1)N=[N+]=[N-])=O)=O
Biological Activity: AcdK is a non-natural amino acid and a precursor of allysine. AcdK allows site-specific incorporation into target proteins in E. coli via the amber suppression strategy. AcdK enables site-specific lysine dimethylation or monomethylation modification of target proteins. AcdK can synthesize site-specific lysine-methylated variants of histone H3 and p53, which is applicable for investigating the substrate specificity and catalytic function of epigenetic enzymes[1].
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AcdK | AcdK is a non-natural amino acid and a precursor of allysine. AcdK allows site-specific incorporation into target proteins in E. coli via the amber suppression strategy. AcdK enables site-specific lysine dimethylation or monomethylation modification of target proteins. AcdK can synthesize site-specific lysine-methylated variants of histone H3 and p53, which is applicable for investigating the substrate specificity and catalytic function of epigenetic enzymes. | |||||||||||||||||||||
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