2098632-04-1
Chemical Structure
DCM-KPV
- CAS No.: 2098632-04-1
- Formula:C40H48N8O4
- Molecular Weight:704.86
InChIKey: JVLZFNOXDLSTHM-SAPNQHFASA-N
SMILES: N#C/C(C#N)=C1C2=CC=CC=C2OC(/C=C/C3=CC=C(N4CCN(CC4)C([C@H](C(C)C)NC([C@H]5N(CCC5)C([C@@H](N)CCCCN)=O)=O)=O)C=C3)=C\1
Biological Activity: DCM-KPV is a fluorescent probe targeting the human intestinal oligopeptide transporter PEPT1/SLC15A1 receptor (λex=480 nm, λem=620-670 nm). DCM-KPV specifically binds to PepT1 via its KPV domain and mediates receptor-targeted internalization, thus effectively accumulating in the cytoplasm and nucleus of cells overexpressing this receptor. DCM-KPV has the advantages of long emission wavelength, high emission efficiency, low photobleaching, and negligible cytotoxicity. DCM-KPV maintains stable fluorescence intensity under continuous illumination, exhibiting extremely high live cell compatibility. DCM-KPV can specifically accumulate at colonic inflammatory sites through the intestinal mucosa, enabling direct non-invasive visual differentiation between chronic and acute ulcerative colitis groups and the normal group[1][2].
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DCM-KPV | DCM-KPV is a fluorescent probe targeting the human intestinal oligopeptide transporter PEPT1/SLC15A1 receptor (λex=480 nm, λem=620-670 nm). DCM-KPV specifically binds to PepT1 via its KPV domain and mediates receptor-targeted internalization, thus effectively accumulating in the cytoplasm and nucleus of cells overexpressing this receptor. DCM-KPV has the advantages of long emission wavelength, high emission efficiency, low photobleaching, and negligible cytotoxicity. DCM-KPV maintains stable fluorescence intensity under continuous illumination, exhibiting extremely high live cell compatibility. DCM-KPV can specifically accumulate at colonic inflammatory sites through the intestinal mucosa, enabling direct non-invasive visual differentiation between chronic and acute ulcerative colitis groups and the normal group. | |||||||||||||||||||||
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References
- [1]. Wang B, et al. A Review on Recent Advances in Peptide‐based Fluorescence Probes and their Potential Applications[J]. ChemistrySelect, 2023, 8(31): e202302216.
- [2]. Zeng M, et al. Peptide Receptor-Targeted Fluorescent Probe: Visualization and Discrimination between Chronic and Acute Ulcerative Colitis. ACS Appl Mater Interfaces. 2017;9(15):13029-13036. [Content Brief]
