2101208-44-8
Chemical Structure
CM03
- CAS No.: 2101208-44-8
- Formula:C34H44N6O6
- Molecular Weight:632.75
IUPAC Name: 2,7-bis(3-morpholinopropyl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone
InChIKey: KCCGFZWBVFNFGW-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2C3=O)N(C(C4=C1C2=C(C=C4NCCN5CCCC5)C(N3CCCN6CCOCC6)=O)=O)CCCN7CCOCC7
Biological Activity: CM03 is a potent DNA G-quadruplexes (G4s) ligand. CM03 can stabilise G4s, downregulating more G4-containing genes as well as increasing incidence of double-strand break events (DSBs) due to torsional strain on DNA and chromatin structure. CM03 has selective potency for pancreatic cancer cells[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CM03 | 98.23% | CM03 is a potent DNA G-quadruplexes (G4s) ligand. CM03 can stabilise G4s, downregulating more G4-containing genes as well as increasing incidence of double-strand break events (DSBs) due to torsional strain on DNA and chromatin structure. CM03 has selective potency for pancreatic cancer cells. | ||||||||||||||||||||
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References
- [1]. Ahmed AA, et al. A G-Quadruplex-Binding Small Molecule and the HDAC Inhibitor SAHA (Vorinostat) Act Synergistically in Gemcitabine-Sensitive and Resistant Pancreatic Cancer Cells. Molecules. 2020 Nov 19;25(22):5407. [Content Brief]
- [2]. Ahmed AA, et al. Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models. ACS Med Chem Lett. 2020 Jul 16;11(8):1634-1644. [Content Brief]
