2101750-19-8
Chemical Structure
2,4-Difluorophenylethynylcobalamin
Synonym(s): F2PhEtyCbl
- CAS No.: 2101750-19-8
- Formula:C70H91CoF2N13O14P
- Molecular Weight:1466.45
InChIKey: SAXFLXPDTWBIGN-WZHZPDAFSA-L
SMILES: C[C@]1([C@](C)2CC(N)=O)[N]([Co+3]([N-]3[C@]1([H])[C@@H]4CC(N)=O)([N](C([C@](C)5CC(N)=O)=C6C)=C7[C@H]5CCC(N)=O)([N](C(C(C)8C)=C7)=C([C@H]8CCC(N)=O)C(C)=C3[C@@]4(CCC(NC[C@H]9C)=O)C)([N](C%10=C%11)=CN([C@@H](O[C@@H]%12CO)[C@]([C@@H]%12O[P]([O-])(O9)=O)([H])O)C%10=CC(C)=C%11C)[C-]#CC(C=CC(F)=C%13)=C%13F)=C6[C@H]2CCC(N)=O
Biological Activity: 2,4-Difluorophenylethynylcobalamin is a potential B12 antivitamin via binding to human B12 -processing enzyme CblC with high affinity (KD=130 nm). 2,4-Difluorophenylethynylcobalamin withstood tailoring by CblC, and stabilizes the ternary complex with the cosubstrate glutathione (GSH)[1]. 2,4-Difluorophenylethynylcobalamin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2,4-Difluorophenylethynylcobalamin | 98.97% | 2,4-Difluorophenylethynylcobalamin is a potential B12 antivitamin via binding to human B12 -processing enzyme CblC with high affinity (KD=130 nm). 2,4-Difluorophenylethynylcobalamin withstood tailoring by CblC, and stabilizes the ternary complex with the cosubstrate glutathione (GSH). 2,4-Difluorophenylethynylcobalamin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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