2101957-05-3
2101957-05-3
Chemical Structure
GNE-886
- CAS No.: 2101957-05-3
- Formula:C28H30N6O3
- Molecular Weight:498.58
IUPAC Name: 6-allyl-N-(1-(6-(3-methoxyphenyl)pyrimidin-4-yl)piperidin-4-yl)-N-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-carboxamide
InChIKey: ZKIRTFGYQVXNGL-UHFFFAOYSA-N
SMILES: O=C(C1=CN(CC=C)C(C2=C1C=CN2)=O)N(C3CCN(C4=NC=NC(C5=CC=CC(OC)=C5)=C4)CC3)C
Biological Activity: GNE-886 (Compound 21) is a potent and selective inhibitor of Cat eye syndrome chromosome region candidate 2 bromodomain (CECR2) (BRD) with an IC50 value of 0.016 µM and an EC50 value of 370 nM. GNE-886 also inhibits BRD9 with an IC50 value of 1.6 µM[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GNE-886 | 99.81% | GNE-886 (Compound 21) is a potent and selective inhibitor of Cat eye syndrome chromosome region candidate 2 bromodomain (CECR2) (BRD) with an IC50 value of 0.016 µM and an EC50 value of 370 nM. GNE-886 also inhibits BRD9 with an IC50 value of 1.6 µM. | ||||||||||||||||||||
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