2101981-60-4
Chemical Structure
(R)-DOTMA
- CAS No.: 2101981-60-4
- Formula:C42H84ClNO2
- Molecular Weight:670.59
IUPAC Name: (R)-N,N,N-trimethyl-2,3-bis(((Z)-octadec-9-en-1-yl)oxy)propan-1-aminium chloride
InChIKey: LDGWQMRUWMSZIU-YKBXHWKCSA-M
SMILES: [C@@H](COCCCCCCCC/C=C\CCCCCCCC)(OCCCCCCCC/C=C\CCCCCCCC)C[N+](C)(C)C.[Cl-]
Biological Activity: (R)-DOTMA is a cationic lipid that can be used to construct lipid nanoparticles and lipoplexes. (R)-DOTMA binds nucleic acid molecules such as mRNA through electrostatic interactions, facilitating nucleic acid encapsulation and cellular delivery. (R)-DOTMA can form lipid systems with DOPE (HY-112005) or cholesterol (HY-N0322). (R)-DOTMA is applicable to mRNA delivery, vaccine development, cancer immunotherapy and gene editing research[1][2].
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(R)-DOTMA | (R)-DOTMA is a cationic lipid that can be used to construct lipid nanoparticles and lipoplexes. (R)-DOTMA binds nucleic acid molecules such as mRNA through electrostatic interactions, facilitating nucleic acid encapsulation and cellular delivery. (R)-DOTMA can form lipid systems with DOPE (HY-112005) or cholesterol (HY-N0322). (R)-DOTMA is applicable to mRNA delivery, vaccine development, cancer immunotherapy and gene editing research. | |||||||||||||||||||||
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References
- [1]. Rosigkeit S, et al. Monitoring Translation Activity of mRNA-Loaded Nanoparticles in Mice. Molecular pharmaceutics. 2018 Sep 04;15(9):3909-3919. [Content Brief]
- [2]. Graewert MA, et al. Quantitative size-resolved characterization of mRNA nanoparticles by in-line coupling of asymmetrical-flow field-flow fractionation with small angle X-ray scattering. Scientific reports. 2023 Sep 22;13(1):15764. [Content Brief]
