2102179-29-1
2102179-29-1
Chemical Structure
TRPM8 antagonist 3
- CAS No.: 2102179-29-1
- Formula:C13H12N2O4S
- Molecular Weight:292.31
IUPAC Name: (4-hydroxy-2-(2-hydroxyphenyl)thiazol-5-yl)(isoxazolidin-2-yl)methanone
InChIKey: BKUQCBLRBYEPFS-UHFFFAOYSA-N
SMILES: O=C(N1OCCC1)C2=C(O)N=C(C3=C(O)C=CC=C3)S2
Biological Activity: TRPM8 antagonist 3 is a novel TRPM8 blocker with an IC50 value of 11 nM.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TRPM8 antagonist 3 | 99.51% | TRPM8 antagonist 3 is a novel TRPM8 blocker with an IC50 value of 11 nM. | ||||||||||||||||||||
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MHY 553 | MHY 553 is a PPARα agonist that is effective when taken orally. MHY 553 helps alleviate liver fat accumulation by increasing fatty acid oxidation and reducing inflammation during the aging process. MHY 553 inhibits the accumulation of triglycerides induced by liver X receptor agonists in HepG2 cells. MHY 553 significantly suppresses the expression of inflammatory mRNA in aging rats. | |||||||||||||||||||||
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Febuxostat impurity 9 | Febuxostat impurity 9 (Desisobutyl febuxostat) is an impurity of Febuxostat. | |||||||||||||||||||||
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(E)-HBT-O | (E)-HBT-O is an isomer of HBT-O. HBT-O is a fluorescent probe used to monitor subtle pH fluctuations in living cells. | |||||||||||||||||||||
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SJ6145 | SJ6145 is a potent ligand for KLHDC2SBD, with the Kd of 16.9 μM in SPR test, IC50 value of 42 μM in inhibiting KLHDC2SBD binding to a di-Gly degron peptide test. | |||||||||||||||||||||
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CIB-L43 | 99.71% | CIB-L43 is an orally active TRBP inhibitor (KD = 4.78 nM) and enhances disruption of TRBP-Dicer interactions (IC50 = 2.34 μM). CIB-L43 suppresses oncogenic miR-21 biosynthesis, increasing PTEN and Smad7 expression and inhibiting AKT and TGF-β signaling, thereby reducing HCC cell proliferation and migration. | ||||||||||||||||||||
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Tyrosinase-IN-50 | 99.50% | Tyrosinase-IN-50 (Compound 14) is a Tyrosinase inhibitor (IC50 is 0.06 μM or 0.16 μM). Tyrosinase-IN-50 inhibits melanogenesis in multiple cell types. Tyrosinase-IN-50 can be used for the research of hyperpigmentation-related diseases and inflammatory diseases. | ||||||||||||||||||||
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Febuxostat impurity 14 | Febuxostat impurity 14 is an impurity of Febuxostat. | |||||||||||||||||||||
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4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid | 4-Methyl-2-[4-(trifluoromethyl) phenyl]-1,3-thiazole-5-carboxylic acid is a substituted thiazole carboxylic acid synthetic intermediate and a metabolite of GW 501516 (HY-10838), which is detected in horse plasma and hair samples after administration. | |||||||||||||||||||||
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Ethyl 2-(3-hydroxyphenyl)-4-methylthiazole-5-carboxylate | Ethyl 2-(3-hydroxyphenyl)-4-methylthiazole-5-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis. | |||||||||||||||||||||
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Febuxostat impurity 2 | Febuxostat impurity 2 is an impurity of Febuxostat. | |||||||||||||||||||||
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