210236-47-8
Chemical Structure
CJ-15208
- CAS No.: 210236-47-8
- Formula:C34H35N5O4
- Molecular Weight:577.67
IUPAC Name: (3S,6S,9S,14aR)-6-((1H-indol-3-yl)methyl)-3,9-dibenzyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone
InChIKey: GIZJWWQFOGQPRY-GCXHJFECSA-N
SMILES: O=C(N[C@H](C(N1[C@@](CCC1)([H])C(N[C@H](C(N2)=O)CC3=CC=CC=C3)=O)=O)CC4=CC=CC=C4)[C@@H]2CC5=CNC6=CC=CC=C56
Biological Activity: CJ-15208 is a potent and selective κ-opioid receptor antagonist with significant opioid activity. CJ-15208 exhibited strong analgesic effects in the warm water tail withdrawal test in mice and was mediated through multiple opioid receptors. The stereoisomers of CJ-15208 exhibited different opioid activity characteristics, for example, one stereoisomer exhibited κ-opioid receptor antagonism, while the other exhibited δ-opioid receptor antagonism. All stereoisomers of CJ-15208 had no significant effects on respiration. The stereoisomers of CJ-15208 did not lead to the development of drug tolerance, which makes it potential in the further development of safe opioid analgesics[1].
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CJ-15208 | CJ-15208 is a potent and selective κ-opioid receptor antagonist with significant opioid activity. CJ-15208 exhibited strong analgesic effects in the warm water tail withdrawal test in mice and was mediated through multiple opioid receptors. The stereoisomers of CJ-15208 exhibited different opioid activity characteristics, for example, one stereoisomer exhibited κ-opioid receptor antagonism, while the other exhibited δ-opioid receptor antagonism. All stereoisomers of CJ-15208 had no significant effects on respiration. The stereoisomers of CJ-15208 did not lead to the development of drug tolerance, which makes it potential in the further development of safe opioid analgesics. | |||||||||||||||||||||
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