210344-96-0
Chemical Structure
Z-VEID-FMK
Synonym(s): Z-VE(OMe)ID(OMe)-FMK
- CAS No.: 210344-96-0
- Formula:C31H45FN4O10
- Molecular Weight:652.71
IUPAC Name: methyl (5S,8S,11S,14S)-11-((S)-sec-butyl)-14-(2-fluoroacetyl)-5-isopropyl-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate
InChIKey: YPIHFMWAHMPACV-IREHUOSBSA-N
SMILES: O=C(OCC1=CC=CC=C1)N[C@@H](C(C)C)C(N[C@@H](CCC(OC)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(CF)=O)CC(OC)=O)=O)=O)=O
Biological Activity: Z-VEID-FMK (Z-VE(OMe)ID(OMe)-FMK) is a selective and irreversible caspase-6 peptide inhibitor. Z-VEID-FMK alleviates the drug-induced augmentation of caspase-6 activity, DNA fragmentation, and cell apoptosis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Z-VEID-FMK | 95.0% | Z-VEID-FMK (Z-VE(OMe)ID(OMe)-FMK) is a selective and irreversible caspase-6 peptide inhibitor. Z-VEID-FMK alleviates the drug-induced augmentation of caspase-6 activity, DNA fragmentation, and cell apoptosis. | ||||||||||||||||||||
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References
- [1]. S-T Lee, et al. Apoptotic insults to human HepG2 cells induced by S-(+)-ketamine occurs through activation of a Bax-mitochondria-caspase protease pathway. Br J Anaesth. 2009 Jan;102(1):80-9. [Content Brief]
- [2]. Philippe P Monnier, et al. Involvement of caspase-6 and caspase-8 in neuronal apoptosis and the regenerative failure of injured retinal ganglion cells. J Neurosci. 2011 Jul 20;31(29):10494-505. [Content Brief]
