210826-47-4
Chemical Structure
NP3-146
Synonym(s): NLRP3-IN-5
- CAS No.: 210826-47-4
- Formula:C20H27ClN2O5S
- Molecular Weight:442.96
IUPAC Name: N-((4-chloro-2,6-diisopropylphenyl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide
InChIKey: RTJGVFANTDWUEG-UHFFFAOYSA-N
SMILES: O=C(NS(=O)(C1=CC(C(C)(C)O)=CO1)=O)NC2=C(C(C)C)C=C(Cl)C=C2C(C)C
Biological Activity: NP3-146 is a NLRP3 inflammasome inhibitor through locking the NACHT domain of NLRP3. NP3-146 shows potent inhibitory activity against IL-1β release with an IC50 value of 0.171 μM in LPS (HY-D1056)/Nigericin (HY-127019)-stimulated BMDM cells. NP3-146 regulates the levels of cleaved Caspase-1 and cleaved IL-1β in cell supernatants. NP3-146 can be used for the research of inflammatory diseases[1][2].
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NP3-146 | NP3-146 is a NLRP3 inflammasome inhibitor through locking the NACHT domain of NLRP3. NP3-146 shows potent inhibitory activity against IL-1β release with an IC50 value of 0.171 μM in LPS (HY-D1056)/Nigericin (HY-127019)-stimulated BMDM cells. NP3-146 regulates the levels of cleaved Caspase-1 and cleaved IL-1β in cell supernatants. NP3-146 can be used for the research of inflammatory diseases. | |||||||||||||||||||||
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References
- [1]. Feng H, et al. Design, synthesis and biological evaluation of sulfonylurea derivatives as NLRP3 inflammasome inhibitors. Bioorg Med Chem Lett. 2024 Dec 1;114:129987. [Content Brief]
- [2]. Harrison D, et al. Discovery and Optimization of Triazolopyrimidinone Derivatives as Selective NLRP3 Inflammasome Inhibitors. ACS Med Chem Lett. 2022 Aug 1;13(8):1321-1328. [Content Brief]
