210891-04-6
Chemical Structure
Edonentan
Synonym(s): BMS 207940
- CAS No.: 210891-04-6
- Formula:C28H32N4O5S
- Molecular Weight:536.64
IUPAC Name: N-((2'-(N-(4,5-dimethylisoxazol-3-yl)sulfamoyl)-4-(oxazol-2-yl)-[1,1'-biphenyl]-2-yl)methyl)-N,3,3-trimethylbutanamide
InChIKey: ORJRYNKVKJAJPY-UHFFFAOYSA-N
SMILES: CC(C)(C)CC(N(CC1=CC(C2=NC=CO2)=CC=C1C3=CC=CC=C3S(=O)(NC4=NOC(C)=C4C)=O)C)=O
Biological Activity: Edonentan (BMS 207940) is an orally active, highly selective endothelin A receptor (ETA receptor) antagonist with a Ki value of 0.01 nM against human targets. Edonentan blocks the pressor response induced by Big Endothelin-1 in conscious normotensive rats and the pressor response induced by ET-1 in conscious normotensive cynomolgus monkeys. Edonentan can be used in research related to cardiovascular diseases[1].
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Edonentan | 99.13% | Edonentan (BMS 207940) is an orally active, highly selective endothelin A receptor (ETA receptor) antagonist with a Ki value of 0.01 nM against human targets. Edonentan blocks the pressor response induced by Big Endothelin-1 in conscious normotensive rats and the pressor response induced by ET-1 in conscious normotensive cynomolgus monkeys. Edonentan can be used in research related to cardiovascular diseases. | ||||||||||||||||||||
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References
- [1]. Murugesan N, et al. Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist. Journal of medicinal chemistry. 2003 Jan 02;46(1):125-37. [Content Brief]
