2110426-27-0
Chemical Structure
JNJ-63576253 free base
Synonym(s): TRC-253 free base
- CAS No.: 2110426-27-0
- Formula:C23H21F3N6O2S
- Molecular Weight:502.51
IUPAC Name: 5-(8-oxo-5-(6-(piperidin-4-yloxy)pyridin-3-yl)-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile
InChIKey: OUEHJEYKNYQVRC-UHFFFAOYSA-N
SMILES: O=C(N(C(N1C2=CC=C(N=C2)OC3CCNCC3)=S)C(C=C4C(F)(F)F)=CN=C4C#N)C51CCC5
Biological Activity: JNJ-63576253 (TRC-253) free base is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 free base can be used for the research of castration-resistant prostate cancer (CRPC)[1].
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JNJ-63576253 free base | JNJ-63576253 (TRC-253) free base is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 free base can be used for the research of castration-resistant prostate cancer (CRPC). | |||||||||||||||||||||
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