2113617-02-8
Chemical Structure
MAP3K14-IN-1
- CAS No.: 2113617-02-8
- Formula:C29H31N7O2
- Molecular Weight:509.61
IUPAC Name: (R)-5-(2-((5-cyano-2-methyl-4-(2-morpholinoethyl)phenyl)amino)pyrimidin-4-yl)-3-(hydroxymethyl)-3-methylindoline-7-carbonitrile
InChIKey: VQBPWNWQPUQVHN-GDLZYMKVSA-N
SMILES: C(O)[C@]1(C)C=2C(=C(C#N)C=C(C2)C3=NC(NC4=CC(C#N)=C(CCN5CCOCC5)C=C4C)=NC=C3)NC1
Biological Activity: MAP3K14-IN-1 (Compound 173) is a MAP3K14 (NIK kinase) inhibitor with an IC50 of 1.8 nM. MAP3K14-IN-1 inhibits the autophosphorylation of MAP3K14 kinase. MAP3K14-IN-1 reduces the level of phosphorylated IKKα in cancer cells. MAP3K14-IN-1 inhibits the proliferation of multiple myeloma cells. MAP3K14-IN-1 can be used in research related to multiple myeloma[1].
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MAP3K14-IN-1 | MAP3K14-IN-1 (Compound 173) is a MAP3K14 (NIK kinase) inhibitor with an IC50 of 1.8 nM. MAP3K14-IN-1 inhibits the autophosphorylation of MAP3K14 kinase. MAP3K14-IN-1 reduces the level of phosphorylated IKKα in cancer cells. MAP3K14-IN-1 inhibits the proliferation of multiple myeloma cells. MAP3K14-IN-1 can be used in research related to multiple myeloma. | |||||||||||||||||||||
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