2114339-57-8
Chemical Structure
Amcenestrant
Synonym(s): SAR439859
- CAS No.: 2114339-57-8
- Formula:C31H30Cl2FNO3
- Molecular Weight:554.48
IUPAC Name: (S)-8-(2,4-dichlorophenyl)-9-(4-((1-(3-fluoropropyl)pyrrolidin-3-yl)oxy)phenyl)-6,7-dihydro-5H-benzo[7]annulene-3-carboxylic acid
InChIKey: KISZAGQTIXIVAR-VWLOTQADSA-N
SMILES: O=C(C1=CC=C(C(C2=CC=C(O[C@@H]3CN(CCCF)CC3)C=C2)=C(C4=CC=C(Cl)C=C4Cl)CCC5)C5=C1)O
Biological Activity: SAR439859 (compound 43d) is an orally active, non-steroidal, and selective estrogen receptor degrader (SERD). SAR439859 is an effective ER antagonist with ER degradation activity, an EC50 of 0.2 nM. SAR439859 can show potent anti-tumor effects and limited cross-resistance in ER+ breast cancer.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Amcenestrant | 99.79% | SAR439859 (compound 43d) is an orally active, non-steroidal, and selective estrogen receptor degrader (SERD). SAR439859 is an effective ER antagonist with ER degradation activity, an EC50 of 0.2 nM. SAR439859 can show potent anti-tumor effects and limited cross-resistance in ER+ breast cancer. | ||||||||||||||||||||
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