21170-34-3
21170-34-3
Chemical Structure
NSC-88915
- CAS No.: 21170-34-3
- Formula:C27H33BrO5S
- Molecular Weight:549.52
IUPAC Name: 2-((8S,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl 4-bromobenzenesulfonate
InChIKey: ZQNARVKYKGBJES-YNHSGCSHSA-N
SMILES: O=S(C1=CC=C(C=C1)Br)(OCC([C@H]2CC[C@]3([C@@]4(CCC5=CC(CC[C@@]5([C@]4(CC[C@]23C)[H])C)=O)[H])[H])=O)=O
Biological Activity: NSC-88915 is an inhibitor of Tdp1 with an IC50 of 7.7 μM. NSC-88915 is a C21-subsitited progesterone derivative[1][2].
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NSC-88915 | NSC-88915 is an inhibitor of Tdp1 with an IC50 of 7.7 μM. NSC-88915 is a C21-subsitited progesterone derivative. | |||||||||||||||||||||
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References
- [1]. Dexheimer, T. S., et al., (2009). 4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors. Journal of medicinal chemistry, 52(22), 7122-7131. [Content Brief]
- [2]. Nguyen, T. X., et al., (2012). Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors. Journal of medicinal chemistry, 55(9), 4457-4478. [Content Brief]
