21203-86-1
21203-86-1
Chemical Structure
2-PPA
- CAS No.: 21203-86-1
- Formula:C11H10N2
- Molecular Weight:170.22
IUPAC Name: 2-phenylpyridin-4-amine
InChIKey: CHVKPWIABFICLK-UHFFFAOYSA-N
SMILES: NC1=CC(C2=CC=CC=C2)=NC=C1
Biological Activity: 2-PPA is a lysosomal potassium and proton channel TMEM175 pore blocker. 2-PPA binds at a TMEM175 pore site to occlude potassium and proton ion permeation pathways. 2-PPA increases lysosomal macromolecule catabolism, accelerates macropinocytosis. 2-PPA binds to hepatic protein in covalent. 2-PPA can be used for the research of Parkinson's disease[1][2].
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2-PPA | 99.98% | 2-PPA is a lysosomal potassium and proton channel TMEM175 pore blocker. 2-PPA binds at a TMEM175 pore site to occlude potassium and proton ion permeation pathways. 2-PPA increases lysosomal macromolecule catabolism, accelerates macropinocytosis. 2-PPA binds to hepatic protein in covalent. 2-PPA can be used for the research of Parkinson's disease. | ||||||||||||||||||||
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References
- [1]. Oh S, et al. Discovery of Selective Inhibitors for the Lysosomal Parkinson's Disease Channel TMEM175. J Am Chem Soc. 2024;146(33):23230-23239. [Content Brief]
- [2]. Li C, et al. Differential effects of fibrates on the metabolic activation of 2-phenylpropionic acid in rats. Drug Metab Dispos. 2008;36(4):682-687. [Content Brief]
