2123480-72-6
2123480-72-6
Chemical Structure
UbcH5c-IN-1
- CAS No.: 2123480-72-6
- Formula:C22H21BrO3
- Molecular Weight:413.30
IUPAC Name: (3aS,9bR)-8-((2-bromobenzyl)oxy)-6,9-dimethyl-3-methylene-3a,4,5,9b-tetrahydronaphtho[1,2-b]furan-2(3H)-one
InChIKey: IRBNWCSCHCJSLT-LAUBAEHRSA-N
SMILES: BrC1=CC=CC=C1COC2=C(C)C([C@H](OC(C3=C)=O)[C@H]3CC4)=C4C(C)=C2
Biological Activity: UbcH5c-IN-1 (compound 6d) is a potent and selective small-molecule inhibitor of Ubiquitin-conjugating enzyme UbcH5c, with a Kd of 283 nM for E2 UbcH5c-IN-1 by covalent binding with Cys85. A promising lead compound for the development of new antirheumatoid arthritis (RA) agent[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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UbcH5c-IN-1 | 99.84% | UbcH5c-IN-1 (compound 6d) is a potent and selective small-molecule inhibitor of Ubiquitin-conjugating enzyme UbcH5c, with a Kd of 283 nM for E2 UbcH5c-IN-1 by covalent binding with Cys85. A promising lead compound for the development of new antirheumatoid arthritis (RA) agent. | ||||||||||||||||||||
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