213262-83-0
Chemical Structure
AN-7
- CAS No.: 213262-83-0
- Formula:C9H19O6P
- Molecular Weight:254.22
IUPAC Name: ((diethoxyphosphoryl)oxy)methyl butyrate
InChIKey: UGIGKLCVADLBRB-UHFFFAOYSA-N
SMILES: CCCC(OCOP(OCC)(OCC)=O)=O
Biological Activity: AN-7 is an orally active histone deacetylase (HDAC) inhibitor that induces histone hyperacetylation and differentiation in vitro and in vivo, and inhibits the proliferation of human prostate 22Rv1 cancer cells. AN-7 can increase the expression of the pro-apoptotic protein Bax, reduce the expression of the anti-apoptotic protein Bcl-2, and promote apoptosis by activating caspase-3, and can be used in the study of prostate cancer[1].
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AN-7 | AN-7 is an orally active histone deacetylase (HDAC) inhibitor that induces histone hyperacetylation and differentiation in vitro and in vivo, and inhibits the proliferation of human prostate 22Rv1 cancer cells. AN-7 can increase the expression of the pro-apoptotic protein Bax, reduce the expression of the anti-apoptotic protein Bcl-2, and promote apoptosis by activating caspase-3, and can be used in the study of prostate cancer. | |||||||||||||||||||||
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