2135514-20-2
Chemical Structure
APJ receptor agonist 5
- CAS No.: 2135514-20-2
- Formula:C26H29N3O6
- Molecular Weight:479.52
IUPAC Name: (R)-1-(2,6-dimethoxyphenyl)-2-(ethoxymethyl)-6-hydroxy-5-(3-phenylpyrrolidine-1-carbonyl)pyrimidin-4(1H)-one
InChIKey: KKVOZQKVYSKADL-SFHVURJKSA-N
SMILES: CCOCC(N(C1=C(C=CC=C1OC)OC)C(O)=C2C(N3C[C@](C4=CC=CC=C4)([H])CC3)=O)=NC2=O
Biological Activity: APJ receptor agonist 5 (compound 3) is a potent and orally active agonist of apelin receptor (APJ) with an EC50 of 0.4 nM. APJ receptor agonist 5 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 5 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 5 leads to improved cardiac function and can be used for researching the HF disease[1].
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APJ receptor agonist 5 | APJ receptor agonist 5 (compound 3) is a potent and orally active agonist of apelin receptor (APJ) with an EC50 of 0.4 nM. APJ receptor agonist 5 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 5 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 5 leads to improved cardiac function and can be used for researching the HF disease. | |||||||||||||||||||||
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