2135743-21-2
Chemical Structure
β2AR antagonist 1
- CAS No.: 2135743-21-2
- Formula:C41H51BrN4O9
- Molecular Weight:823.77
IUPAC Name: (4S,7S)-7-(3-bromobenzyl)-4-(4-carbamoylbenzyl)-1-cyclohexyl-2,5,8-trioxo-1-phenyl-12,15,18-trioxa-3,6,9-triazaicosan-20-oic acid
InChIKey: LKQBHDWHOYRIRJ-FWBANIIHSA-N
SMILES: NC(C(C=C1)=CC=C1C[C@@H](C(N[C@H](C(NCCOCCOCCOCC(O)=O)=O)CC2=CC(Br)=CC=C2)=O)NC(C(C3=CC=CC=C3)C4CCCCC4)=O)=O
Biological Activity: β2AR antagonist 1 is a potent β2-adrenergic receptor (β2AR) inhibitor. β2AR antagonist 1 exhibits high selectivity for β2AR over β1AR, vasopressin receptor type 2, and angiotensin type 1 receptor. β2AR antagonist 1 stabilizes the inactive conformation of β2AR and interferes with its coupling to G proteins and β-arrestins[1].
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β2AR antagonist 1 | β2AR antagonist 1 is a potent β2-adrenergic receptor (β2AR) inhibitor. β2AR antagonist 1 exhibits high selectivity for β2AR over β1AR, vasopressin receptor type 2, and angiotensin type 1 receptor. β2AR antagonist 1 stabilizes the inactive conformation of β2AR and interferes with its coupling to G proteins and β-arrestins. | |||||||||||||||||||||
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